Process Scale-Up from Demonstration Batch Filtration to Commercial Continuous Filtration
This article will follow the process filtration approach developed for each technology stage gate starting from batch filtration in the lab to continuous filtration for the full-scale commercial operation. The article begins with a discussion of each stage-gate and how to avoid the “cookie-cutter” approach to these types of projects. Process engineers must not “jump to conclusions”, a reference from Sherlock Holmes and Dr. John Watson who prove time and again is that there is no benefit to jumping to conclusions. Therefore, laboratory / bench top filtration testing is covered for problem analysis, technology selection and pilot and demonstration scale-up. The paper continues with the filtration testing and then scale-up to the commercial size. Finally, the paper concludes with a general review of the problem-solving skills of Holmes and Watson and how these skills can be utilized by process engineers as a framework for “idea-generation” when analyzing a new process scale-up.
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